Currently, patients monitor blood sugars closely and quickly realize if their pump is malfunctioning.
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“I worry that there could be an increased risk of diabetic ketoacidosis if any of the parts of the device malfunction (including the patch on the skin). What are the risks of the device for people with type 1 diabetes?Įxperts expressed some potential concerns about the new device. “There is no substitution for the glucose-detecting abilities of islet cells no closed-loop insulin pump can possibly mimic the blood sugar control provided by islet cells.” This device could be a game changer for people with type 1 diabetes, according to Dr. This is an exciting development that can hopefully open doors for new treatment options to become available in the near future.” They showed how mice rendered diabetic could improve blood glucose levels with transplanted cells without requiring interventions to prevent an autoimmune response.
In this study, the group from MIT presents evidence of the sustainability of a device that prevents environments of low oxygen, which would be a threat to the chances of survival of the transplanted cells. “Without oxygen, these cells die and fail. “Historically, this approach has been difficult to maintain due to an inability to provide a good oxygen supply to those implanted cells,” Dr. Eliud Sifonte, an endocrinologist at NYU Langone Medical Associates, who was not involved in the study. “This technology allows for an improvement in the current approach to implantation of units containing cells that produce insulin in response to blood glucose levels without requiring invasive surgery,” said Dr. “We hope to see this technology in humans within at most four years.”Īlthough the researchers remained focused on treating diabetes, they indicate this kind of device might be able to be adapted to treat other illnesses that require repeated delivery of therapeutic proteins. “We are eager to see this technology translate, but it does take time,” said Dan Anderson, PhD, the study’s lead author and a professor of chemistry at MIT. They expect this device to be about the size of a stick of chewing gum. Researchers hope to create a larger version of the device and test it in people with type 1 diabetes. The device has not yet been tested in humans. MIT researchers said the device kept glucose levels stable for at least one month when implanted into mice. How could an implantable device help control type 1 diabetes? Conceptually, implantable islet cells that do not require immune suppression and create their own source of oxygen is nothing short of brilliant.” Long-term success rates are low, and patients require lifelong immunosuppressive therapy. “Currently, islet cell transplant is limited to patients with a history of severe metabolic complications and consistent failure of insulin-based therapies. Caroline Messer, an endocrinologist at Northwell Lenox Hill Hospital in New York, not involved in the study, explained to Medical News Today: The researchers said the device could potentially replace insulin injections in people with type 1 diabetes.ĭr. To combat this, the scientists created an oxygen factory on the device, allowing it to generate oxygen by splitting water vapor in the body. Previous devices made for the same purpose failed and stopped producing insulin because they ran out of oxygen needed to create the insulin. The MIT engineers reported that the small implantable device could carry hundreds of thousands of insulin-producing islet cells. Their findings were published on September 18 in The Proceeding of the National Academy of Science. Researchers at the Massachusetts Institute of Technology (MIT) say they have created a device for people with type 1 diabetes that may help produce insulin when needed.
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